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Publications (2000 - Current) |
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| Tan L, Chen L, Yang, H, Jin B, Kim G, Im YJ. Structural basis for activation of fungal sterol receptor Upc2 and azole resistance. Nature Chemical Biology. 2022 Oct (DOI 10.1038/s41589-022-01117-0) Highlighted in News & Views (IF: 16.29) | ||
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Chen L, Tan L, Im YJ. Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Acta Crystallogr D Struct Biol. 2022 Jul 1;78(Pt 7):853-864 (IF: 5.70)
Kwak JS, Lee Y, Yang J, Kim SK, Shin Y, Kim HJ, Choi JH, Im YJ, Kim MJ, Lee Yu K, Chang You J, Chun JS. Characterization of rhodanine derivatives as potential disease-modifying drugs for experimental mouse osteoarthritis. Osteoarthritis and Cartilage. 2022 May 2:S1063-4584(22)00721-X
Khan H, Chen L, Tan L, Im YJ. Structural basis of human PDZD8-Rab7 interaction for the ER-late endosome tethering. Sci Rep. 2021 Sep 22;11(1):18859. (IF: 5.00)
Tong J, Tan L, Im YJ. Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins. PLoS One. 2021 Apr 15; 16(4):e0248781.
Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH. Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17003-17010
Ryu M, Sung CK, Im YJ, Chun C. Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract. Molecules. 2020 Feb 27;25(5).
Tan L, Tong J, Chun C, Im YJ. Structural analysis of human sterol transfer protein STARD4. Biochem Biophys Res Commun. 2019 Dec 3;520(2):466-472.
Guo RH, Im YJ, Shin SI, Jeong K, Rhee JH, Kim YR. Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulate PAK1- and MAPK-dependent cytoskeleton reorganization and cell death. Emerg Microbes Infect. 2019;8(1):934-945.
Tong J, Tan L, Chun C, Im YJ.
Structural basis of human ORP1-Rab7
interaction for the late-endosome and lysosome targeting.
PLoS One. 2019 Feb 5;14(2):e0211724. Tong J, Manik MK, Im YJ. Structural basis of sterol recognition and non-vesicluar transport by lipid transfer proteins anchored at membrane contact sites. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E856-E865. (IF:9.661) 언론기사 보기: 에듀동아 매일일보
Tong J, Im YJ, Crystallization and X-ray crystallographic analysis of the PH-like domain of lipid transfer protein anchored at membrane contact sites from Saccharomyces cerevisiae. Biodesign. 2017 Dec 31;5:135-139.
Lee MA, Tan L, Yang H, Im YG, Im YJ. Structures of PPAR g complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs. Sci Rep. 2017 Dec 4;7(1):16837. (IF: 4.259)
Manik MK, Yang H, Tong J, Im YJ. Structure of yeast OSBP-related protein Osh1 reveals key determinants for lipid transport and protein targeting at the nucleus-vacuole junction. Structure. 2017 Apr 4;25(4):617-629. (IF: 5.237)
Cai B, Liao A, Lee KK, Ban JS, Yang HS, Im YJ, Chun C. Design, synthesis of methotrexate-diosgenin conjugates and biological evaluation of their effect on methotrexate transport-resistant cells. Steroids. 2016 Dec;116:45-51.
Choi MJ, Won EJ, Shin JH, Kim SH, Lee WG, Kim MN, Lee K, Shin MG, Suh SP, Ryang DW, Im YJ. Resistance Mechanisms and Clinical Features of Fluconazole Non-Susceptible Candida tropicalis Isolates: Comparison with Fluconazole Less-Susceptible Isolates. Antimicrob Agents Chemother. 2016 Apr 4;60(6):3653-3661.
Tong J, Manik KM, Yang H, Im YJ. Structural insights into nonvesicular lipid transport by the oxysterol binding protein homologue family. BBA Molecular and Cell Biology of Lipids. 2016 Aug;1861(8 Pt B):928-39 (IF:5.16) Review Article
Youn HS, Kim TG, Kim MK, Kang GB, Kang JY, Lee JG, An JY, Park KR, Lee Y, Im YJ, Lee JH, Eom SH. Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis. Sci Rep. 2016 Jan 25;6:19681. (IF:5.58)
Yang H, Tong J, Lee CW, Ha S, Eom SH, Im YJ. Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2. Nature Communications. 2015 Feb 6; 6:6129 (IF:11.47) PDB: 4N9N 언론 기사 보기 : '진균 아졸계 항생제 내성원인 규명' 중앙일보 의학신문
Tong J, Yang H, Eom SH, Chun C, Im YJ. Structure of the GH1 domain of guanylate kinase-associated protein from Rattus norvegicus. Biochem Biophys Res Commun. 2014 Sep 12; 452(1):130-5
Tong J, Yang H, Im YJ. Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2014 July;70:949-54
Tong J, Yang H, Yang H, Eom SH, Im YJ. Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins. Structure. 2013 July 2; 21(7):1203-13 (IF:6.347) PDB: ORD-PI4P, PH-T4L This article was seleted for Previews in the Journal. Yang H, Tong J, Leonard AT, Im YJ. Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles. FEBS Lett. 2013 Jun 5;587(11):1610-6. (IF:3.538) PDB: Sfh3-PI Ha S, Tong J, Yang H, Youn HS, Eom SH, Im YJ. Crystallization and preliminary X-ray crystallographic analysis of sterol transcription factor Upc2 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):147-52 Tong J, Yang H, Ha S, Lee Y, Eom SH, Im YJ. Crystallization and preliminary X-ray crystallographic analysis of the oxysterol-binding protein Osh3 from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1498-502 Kim S, Liu F, Im YJ, Stephen AG, Fivash MJ, Waheed AA, Freed EO, Fisher RJ, Hurley JH, Burke TR. Elucidation of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands. ACS Med Chem Lett. 2011 May 11; 2(5):337--341 Im YJ, Kuo L, Ren X, Burgos PV, Zhao XZ, Liu F, Burke TR, Bonifacino JS, Free EO, Hurley JH. Crystallographic and Functional Analysis of the ESCRT-I/HIV-1 Gag PTAP Interaction. Structure. 2010 Nov 10;18(11):1536-47 (IF: 6.347) Im YJ, Kang GB, Lee JH, Park KR, Song HE, Kim E, Song WK, Park D, Eom SH. Structural Basis for Asymmetric Association of the betaPIX Coiled Coil and Shank PDZ. J Mol Biol. 2010 Mar 26;397(2):457-66 (IF: 4.001) PDB: bPIX-PDZ Reider A, Barker SL, Mishra SK, Im YJ, Maldonado -Baez L, Hurley JH, Traub LM, Wendland B. Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J. 2009 Oct 21;28(20):3103-16. (IF: 8.3)Im YJ, Wollert T, Boura E, Hurley JH. Structure and function of the ESCRT II -III interface in multivesicular body biogenesis. Dev Cell. 2009 Aug;17(2):234-43. (IF: 14.03)
Wollert T, Yang D, Ren X, Lee HH, Im YJ, Hurley JH. The ESCRT machinery at a glance. J Cell Sci. 2009 Jul 1;122(Pt 13):2163 -6. (IF: 6.2)Hurley JH, Im YJ, Lee HH, Ren X, Wollert T, Yang D. Piecing together the ESCRTs. Biochem Soc Trans. 2009 Feb;37(Pt 1):161 -6. (IF: 3.0)Im YJ, Hurley JH. Integrated structural model and membrane targeting mechanism of the human ESCRT -II complex. Dev Cell. 2008 Jun;14(6):902-13. (Cover Article) (IF: 14.03) -binding protein-related proteins and phosphoinositides. J Cell Biol. 2006 Apr 10;173(1):107-19. (IF: 9.1)Im YJ, Raychaudhuri S, Prinz WA, Hurley JH. Structural mechanism for sterol sensing and transport by OSBP -related proteins. Nature. 2005 Sep 1;437(7055):154-8. (IF: 31.4)
Rho SH, Park HH, Kang GB, Im YJ, Kang MS, LimBK, Seong IS, Seol J, Chung CH, Wang J, Eom SH. Crystal structure of Bacillus subtilis CodW, a noncanonical HslV -like peptidase with an impaired catalytic apparatus. Proteins. 2008 May 1;71(2):1020-6. (IF: 3.4)Kim MK, Cho MK, Song HE, Kim D, Park BH, Lee JH, Kang GB, Kim SH, Im YJ, Lee DS, Eom SH. Crystal structure of UDP -N-acetylenolpyruvylglucosamine reductase (MurB) from Thermus caldophilus. Proteins. 2007 Feb 15;66(3):751-4. (IF: 3.4)Lee JH, Im YJ, Bae J, Kim D, Kim MK, Kang GB, Lee DS, Eom SH. Crystal structure of Thermus caldophilus phosphoglycerate kinase in the open conformation. Biochem Biophys Res Commun. 2006 Dec 1;350(4):1044 -9. (IF: 2.6)Lee JH, Bae J, Kim D, Choi Y, Im YJ, Koh S, Kim JS, Kim MK, Kang GB, Hong SI, Lee DS, Eom SH. Stereoselectivity of fructose -1,6-bisphosphate aldolase in Thermus caldophilus. Biochem Biophys Res Commun. 2006 Sep 1;347(3):616-25. (IF: 2.6)Lee JH, Na Y, Song HE, Kim D, Park BH, Rho SH, Im YJ, Kim MK, Kang GB, Lee DS, Eom SH. Crystal structure of the apo form of D -alanine: D-alanine ligase (Ddl) from Thermus caldophilus: a basis for the substrate-induced conformational changes. Proteins. 2006 Sep 1;64(4):1078-82. (IF: 3.4)Lee JH, Park SJ, Rho SH, Im YJ, Kim MK, Kang GB, Eom SH. Crystallization and preliminary X-ray crystallographic analysis of the GluR0 ligand -binding core from Nostoc punctiforme. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):1020-2. (IF: 0.6)Kim MK, Im YJ, Lee JH, Eom SH. Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori. Proteins. 2006 Apr 1;63(1):252 -5. (IF: 3.4)Lee JH, Kim SY, Rho SH, Im YJ, Kim YR, Kim MK, Kang GB, Rhee JH, Eom SH. Crystallization and preliminary X -ray crystallographic analysis of PAS factor from Vibrio vulnificus. Mol Cells. 2005 Dec 31;20(3):361-3. (IF: 2.0)Lee JH, Yang ST, Rho SH, Im YJ, Kim SY, Kim YR, Kim MK, Kang GB, Kim JI, RheeJH, Eom SH. Crystal structure and functional studies reveal that PAS factor from Vibrio vulnificus is a novel member of the saposin -fold family. J Mol Biol. 2006 Jan 20;355(3):491-500. (IF: 4.1)Kang GB, Kim YS, Im YJ, Rho SH, Lee JH, Eom SH. Crystal structure of NH3 -dependent NAD+ synthetase from Helicobacter pylori. Proteins. 2005 Mar 1;58(4):985-8. (IF: 3.4) -7. (IF: 5.5)Lee JH, Im YJ, Rho SH, Park SH, Kim MK, Cho SJ, Kim TY, Oh JH, Shin HJ, Lee DS, Eom SH. Crystallization and preliminary X -ray analysis of class II fructose-1,6-bisphosphate aldolase from Thermus caldophilus. Protein Pept Lett. 2003 Oct;10(5):511-5. (IF: 1.3)Kang GB, Kim YS, Im YJ, Rho SH, Eom SH. Crystallization and X -ray analysis of NH3-dependent NAD+ synthetase from Helicobacter pylori. Protein Pept Lett. 2003 Aug;10(4):418-21. (IF: 1.3)Im YJ, Lee JH, Park SH, Park SJ, Rho SH, Kang GB, Kim E, Eom SH. Crystal structure of the Shank PDZ -ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization. J Biol Chem. 2003 Nov 28;278(48):48099-104. (IF: 5.5)Lee JH, Im YJ, Rho SH, Park SH,Kang GB, Cho SJ, Kim TY, Shin HJ, Lee DS, Eom SH. Crystallization and preliminary X -ray crystallographic studies of phosphoglycerate kinase from Thermus caldophilus. Mol Cells. 2003 Jun 30;15(3):370-2. (IF: 2.0)Kim MK, Song HE, Kim YS, Rho SH, Im YJ, Lee JH, Kang GB, Eom SH. Crystallization and preliminary X -ray crystallographic analysis of orotate phosphoribosyltransferase from Helicobacter pylori. Mol Cells. 2003 Jun 30;15(3):361-3. (IF: 2.0)Kim MK, Kim YS, Rho SH, Im YJ, Lee JH, Kang GB, Eom SH. Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase of Helicobacter pylori. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1265-6. (IF: 2.9) -7. (IF: 5.5)Park SH, Im YJ, Rho SH, Lee JH, Yang S, Kim E, Eom SH. Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus. Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1353-5. (IF: 2.9)Park SH, Im YJ, Rho SH, Lee JH, Yang S, Kim E, Eom SH. Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate -receptor interacting protein 1 (GRIP1) from Rattus norvegicus. Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1063-5. (IF: 2.9) -24. (IF: 3.1)Kim YS, Im YJ, Rho SH, Sriprapundh D, Vieille C, Suh SW, Zeikus JG, Eom SH. Crystallization and preliminary X -ray studies of Trp138Phe/Val185Thr xylose isomerases from Thermotoga neapolitana and Thermoanaerobacterium thermosulfurigenes. Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt11):1686-8. (IF: 2.9)Kim JJ, Rho SH, Im YJ, Kim EJ, Eom SH. Crystallization and preliminary X -ray diffraction studies of the guanylate kinase-like domain of PSD-95 protein from rat. Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):616-7. (IF: 2.9)Kwak JE, Ha KS, Lee JY, Im YJ, Park SH, Eom SH, Suh SW. Crystallization and preliminary X-ray crystallographic analysis of the surE protein from Thermotoga maritima. Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):612-3. (IF: 2.9)Wang J, Song JJ, Franklin MC, Kamtekar S, Im YJ, Rho SH, Seong IS, Lee CS, Chung CH, Eom SH. Crystal structures of the HslVU peptidase -ATPase complex reveal an ATP-dependent proteolysis mechanism. Structure. 2001 Feb 7;9(2):177-84. (IF: 5.4)Im YJ, Park CM, Kim JI, Yang SS, Kang JG, Rho SH, Kim JI, Song WK, Song PS, Eom SH. Crystallization and preliminary X -ray crystallographic studies of response regulator for cyanobacterial phytochrome, Rcp1. Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1446-8. (IF: 2.9)
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